Ein genormter Test zur Bestimmung der Resistenzentwicklung bei Mikroorganismen gegen Biozide

The aim of this project is to develop a standardized microbiological test method to determine the potential for emergence of resistance and cross-resistance in the use of surface disinfectants and antimicrobial surfaces. The focus is on the emergence of resistance to disinfectants and material protection agents through de novo mutations. These resistances may pose a particular risk because they confer cross-resistance to antibiotics.
Disinfectants and antimicrobial material coatings are approved under the EU Biocides Regulation. The regulation provides for assessment of the risk of emergence of resistance and cross-resistance, but currently lacks standardized test methods to provide a framework for assessment by industrial applicants and assessing authorities. The test method to be developed in the project, based on efficacy tests for surface disinfection (DIN EN 13697:2019 and the DIN EN 16615:2015), will allow biocide manufacturers to have their product tested for resistance development by independent testing institutes. The results will enable authorities to make a better assessment of resistance risk in the context of authorization under the EU Biocides Regulation.
 
The work is being carried out in cooperation with the Federal Institute for Materials Research and Testing (BAM).